Sex linked recessive disorder

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Carrier females who have only one copy of the mutation do not usually express the phenotypealthough differences in X chromosome inactivation can lead to varying degrees of clinical expression in carrier females since some cells will express one X allele and some will express the other. When the father has an X-linked condition, his sons will not be affected. Archived from the original on 15 August Creasy and Resnik's Maternal-Fetal Medicine: Sex-linked diseases are passed down through families through one of the X or Y chromosomes. A single recessive gene on that X chromosome will cause the disease. In each pregnancy, if the mother is a carrier of a certain disease she has only one abnormal X chromosome and the father is not a carrier for the disease, the expected outcome is:. If only one gene in the pair is abnormal, the disease does not occur or it is mild.


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